Effect of KW-8232, a novel anti-osteoporotic agent, on bone loss in sciatic neurectomized rats.

Abstract

The purpose of this study was to evaluate the effects of 3-[bis(4-hydroxyphenyl)methyl]-2-[4-(2-chlorophenyl)-piperazin-1-+ ++ylcarbonyl]-1-(2-dimethylaminoethyl) indole methanesulfonate (KW-8232), a novel anti-osteoporotic agent, on bone loss in neurectomized rats. We also investigated the effect of KW-8232 on bone resorption in this animal model. Male Sprague-Dawley rats underwent unilateral hind-limb immobilization by sciatic neurectomy. KW-8232 (3, 10 and 30 mg/kg, p.o.) was effective in inhibiting femoral bone loss. KW-8232 decreased urinary pyridinoline and deoxypyridinoline excretion. These results indicate that KW-8232 effectively prevents the bone loss due to immobilization.

• Authors: M Uchii, M Takashima, T Sugiyama, N Kosaka
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 78 Issue 2 Pg. 241-3 (Oct 1998) ISSN: 0021-5198 [Print] Japan
• PMID: 9829630 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Indoles
• KW 8232
• Mesylates
• Phosphates
• pyridinoline
• deoxypyridinoline
• Creatinine
• Calcium

Topics

• Amino Acids (urine)
• Animals
• Bone Density (drug effects)
• Calcium (urine)
• Creatinine (urine)
• Femur (drug effects, innervation, physiopathology)
• Indoles (pharmacology, therapeutic use)
• Male
• Mesylates (pharmacology, therapeutic use)
• Osteoporosis (prevention & control)
• Phosphates (urine)
• Rats
• Rats, Sprague-Dawley
• Sciatic Nerve (physiology, surgery)