Abstract |
This study was designed to assess the effect of a nonpeptide vasopressin V1-receptor antagonist, OPC-21268, and a vasopressin V2-receptor antagonist, OPC-31260, on hemodynamics in the early phase and the late phase after myocardial infarction in rats. In the early phase, OPC-21268 (30 mg/kg/day) or OPC-31260 (30 mg/kg/day) was orally administered from day 1 to day 5 after the operation; and hemodynamics were measured at day 5, in the late phase from 10 weeks to 11 weeks and measured at the end of 11 weeks. In the early phase, OPC-21268 reduced the left ventricular end-diastolic pressure (LVEDP) concomitantly with the reduction in systemic blood pressure, but did not change LVEDP in the late phase. OPC-31260 reduced LVEDP and central venous pressure in both phases. OPC-21268 improved hemodynamics only in the early phase and OPC-31260 improved it in both phases.
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Authors | H Fujita, M Yoshiyama, K Takeuchi, T Omura, H Yamagishi, H Iwao, K Miura, J Yoshikawa |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 78
Issue 2
Pg. 229-32
(Oct 1998)
ISSN: 0021-5198 [Print] Japan |
PMID | 9829627
(Publication Type: Journal Article)
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Chemical References |
- Antidiuretic Hormone Receptor Antagonists
- Benzazepines
- Piperidines
- Quinolones
- Vasopressins
- OPC 21268
- mozavaptan
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Topics |
- Administration, Oral
- Animals
- Antidiuretic Hormone Receptor Antagonists
- Benzazepines
(pharmacology, therapeutic use)
- Heart Ventricles
(anatomy & histology)
- Hemodynamics
(drug effects)
- Male
- Myocardial Infarction
(blood, drug therapy, physiopathology)
- Organ Size
(drug effects)
- Piperidines
(pharmacology, therapeutic use)
- Quinolones
(pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- Time Factors
- Vasopressins
(blood, drug effects)
- Ventricular Function, Left
(drug effects)
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