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The effect of vasopressin V1- and V2-receptor antagonists on hemodynamics in early and late phase after myocardial infarction in rats.

Abstract
This study was designed to assess the effect of a nonpeptide vasopressin V1-receptor antagonist, OPC-21268, and a vasopressin V2-receptor antagonist, OPC-31260, on hemodynamics in the early phase and the late phase after myocardial infarction in rats. In the early phase, OPC-21268 (30 mg/kg/day) or OPC-31260 (30 mg/kg/day) was orally administered from day 1 to day 5 after the operation; and hemodynamics were measured at day 5, in the late phase from 10 weeks to 11 weeks and measured at the end of 11 weeks. In the early phase, OPC-21268 reduced the left ventricular end-diastolic pressure (LVEDP) concomitantly with the reduction in systemic blood pressure, but did not change LVEDP in the late phase. OPC-31260 reduced LVEDP and central venous pressure in both phases. OPC-21268 improved hemodynamics only in the early phase and OPC-31260 improved it in both phases.
AuthorsH Fujita, M Yoshiyama, K Takeuchi, T Omura, H Yamagishi, H Iwao, K Miura, J Yoshikawa
JournalJapanese journal of pharmacology (Jpn J Pharmacol) Vol. 78 Issue 2 Pg. 229-32 (Oct 1998) ISSN: 0021-5198 [Print] Japan
PMID9829627 (Publication Type: Journal Article)
Chemical References
  • Antidiuretic Hormone Receptor Antagonists
  • Benzazepines
  • Piperidines
  • Quinolones
  • Vasopressins
  • OPC 21268
  • mozavaptan
Topics
  • Administration, Oral
  • Animals
  • Antidiuretic Hormone Receptor Antagonists
  • Benzazepines (pharmacology, therapeutic use)
  • Heart Ventricles (anatomy & histology)
  • Hemodynamics (drug effects)
  • Male
  • Myocardial Infarction (blood, drug therapy, physiopathology)
  • Organ Size (drug effects)
  • Piperidines (pharmacology, therapeutic use)
  • Quinolones (pharmacology, therapeutic use)
  • Rats
  • Rats, Wistar
  • Time Factors
  • Vasopressins (blood, drug effects)
  • Ventricular Function, Left (drug effects)

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