Abstract | BACKGROUND: METHODS: RESULTS: Testicular volumes, Tanner stages of pubic hair, and genital development were found to be appropriate or slightly delayed for the patients' chronologic age. All 27 patients had normal basal levels of FSH and LH after treatment of Ann Arbor Stage I-IIA HD with 2 courses of OEPA. Stimulated FSH and LH levels were found to be elevated only in rare patients, thus indicating normal endocrine function and spermatogenesis. However, basal and stimulated FSH levels were outside the +2 standard deviation range in 37.5% and 83.3% of patients receiving 2 cycles of OEPA and 2 cycles of COPP chemotherapy, and in 36.4% and 66.7% of patients receiving 2 cycles of OEPA and 4 cycles of COPP chemotherapy, demonstrating a high risk of oligospermia or azoospermia with these regimens. Basal LH levels essentially were normal, whereas stimulated LH levels frequently were elevated. CONCLUSIONS:
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Authors | L Gerres, J H Brämswig, W Schlegel, H Jürgens, G Schellong |
Journal | Cancer
(Cancer)
Vol. 83
Issue 10
Pg. 2217-22
(Nov 15 1998)
ISSN: 0008-543X [Print] United States |
PMID | 9827728
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Procarbazine
- Testosterone
- Vincristine
- Etoposide
- Doxorubicin
- Cyclophosphamide
- Luteinizing Hormone
- Follicle Stimulating Hormone
- Prednisone
- Methotrexate
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Topics |
- Adolescent
- Adult
- Age Factors
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Antineoplastic Combined Chemotherapy Protocols
(pharmacology)
- Cyclophosphamide
(administration & dosage, pharmacology)
- Doxorubicin
(administration & dosage)
- Etoposide
(pharmacology)
- Follicle Stimulating Hormone
(blood)
- Hodgkin Disease
(drug therapy, physiopathology)
- Humans
- Luteinizing Hormone
(blood)
- Male
- Methotrexate
(administration & dosage, pharmacology)
- Prednisone
(administration & dosage)
- Procarbazine
(administration & dosage, pharmacology)
- Puberty
(drug effects, physiology)
- Remission Induction
- Testis
(drug effects, pathology, physiopathology)
- Testosterone
(blood)
- Vincristine
(administration & dosage, pharmacology)
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