Strong increase of 9-hydroxy-10,12-octadecadienoic acid in low density lipoprotein after a hemorrhagic shock.

Abstract

9-hydroxy-10,12-octadecadienoic acid (9-HODE) is generated by lipid peroxidation (LPO) processes in comparison to other marker compounds in at least 10 fold amount. A 10-25 fold increase of this new marker compound in relation to age matched healthy individuals was observed in the low density lipoprotein (LDL) fraction of ten patients suffering from a hemorrhagic shock. The 9-HODE values dropped to normal levels after recovery. Similarly the 9-HODE content in LDL of patients which had to undergo orthopedic surgery--replacement of their arthritic hip joints by endoprosthesis--were investigated. The rather high HODE values dropped also after recovery reflecting obviously the disappearance of inflammatory processes associated with arthritis.

• Authors: P Kreil, G Spiteller, G Johannes, W Wagner
• Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences (Z Naturforsch C J Biosci) 1998 Sep-Oct Vol. 53 Issue 9-10 Pg. 876-82 ISSN: 0939-5075 [Print] Germany
• PMID: 9825542 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Linoleic Acids
• Linoleic Acids, Conjugated
• Lipoproteins, LDL
• 9-hydroxy-10,12-octadecadienoic acid

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Arthroplasty, Replacement, Hip
• Biomarkers (blood)
• Female
• Humans
• Linoleic Acids (blood)
• Linoleic Acids, Conjugated
• Lipoproteins, LDL (blood)
• Male
• Middle Aged
• Postoperative Period
• Reference Values
• Shock, Hemorrhagic (blood)
• Time Factors