Abstract |
The ability of soy protein isolate to reduce the severity of 13-cis retinoic acid (13cRA)-induced hypertriglyceridemia was assessed in an animal model of this condition (rats fed a 13cRA-containing, casein-based diet). Male Fischer 344 rats (N = 7/group) were fed purified diets containing either casein or soy protein isolate and having either no 13cRA or retinoid at a level of 100 mg/kg diet-designated as Groups C, S, C + R, and S + R, respectively. Diet had no effect on either food intake or final body weight, and the serum levels of 13cRA were not significantly different for Groups C + R and S + R. Groups fed diets having 13cRA had significantly (p < 0.05) higher serum triglyceride levels than ones fed the corresponding retinoid-free diets, but the serum triglyceride level for Group S + R was significantly lower than for Group C + R, being 2.99 vs. 6.97 mM (265 vs. 617 mg/dl). Thus, soy protein isolate can reduce the severity of 13cRA-induced hypertriglyceridemia without affecting serum retinoid level.
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Authors | J D Radcliffe, V L Imrhan, A M Hsueh |
Journal | Cancer detection and prevention
(Cancer Detect Prev)
Vol. 22
Issue 6
Pg. 526-32
( 1998)
ISSN: 0361-090X [Print] England |
PMID | 9824375
(Publication Type: Journal Article)
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Chemical References |
- Soybean Proteins
- Isotretinoin
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Topics |
- Animals
- Chemoprevention
- Hypertriglyceridemia
(chemically induced, prevention & control)
- Isotretinoin
(pharmacology)
- Male
- Rats
- Rats, Inbred F344
- Soybean Proteins
(therapeutic use)
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