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[Iatrogenic androgenization].

Abstract
Virilization in postmenopausal women is suspicious for androgen-secreting adrenal or ovarian tumors; however, iatrogenic androgenization needs to be additionally considered. Here we report on a 64-year-old patient who presented clinically with progressive signs of virilization. An adrenal source of androgen excess was excluded, and the patient strictly denied the use of any androgenic medication. Thus, elevated serum levels of testosterone were suspicious of ovarian hyperandrogenism. Shortly before planned surgical exploration, the clinical finding of an extensive vulvar lichen sclerosus pointed towards a possible long-term use of testosterone-containing cremes for symptomatic relief of this disease. Apparently, the patient did not consider the mere topical application of potent agents to be a medication. This case demonstrates that besides adrenal or ovarian sources of hyperandrogenism, iatrogenic androgenization has to be considered.
AuthorsR Mangold, V Heilmann, W G Rossmanith
JournalZentralblatt fur Gynakologie (Zentralbl Gynakol) Vol. 120 Issue 10 Pg. 515-7 ( 1998) ISSN: 0044-4197 [Print] Germany
Vernacular TitleIatrogene Androgenisierung.
PMID9823653 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Testosterone
Topics
  • Administration, Topical
  • Diagnosis, Differential
  • Female
  • Humans
  • Hyperandrogenism (chemically induced)
  • Lichen Sclerosus et Atrophicus (drug therapy)
  • Middle Aged
  • Testosterone (administration & dosage, adverse effects)
  • Virilism (chemically induced)
  • Vulvar Diseases (drug therapy)

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