ND-2001 suppresses lung metastasis of human renal cancer cells in athymic mice.

Abstract

Explants of highly metastatic human renal cell carcinoma SN12Cpm6 cells in athymic mice were treated with sodium D-glucaro-delta-lactam (sodium 5-amino-5-deoxy-D-glucosaccharic acid-delta-lactam; ND-2001). ND-2001 (50 micrograms/ml) caused 78% inhibition of lung metastasis of SN12Cpm6 cells (two of five animals remaining metastasis free). The in vitro tumor cell invasion assay showed that ND-2001 (100 micrograms/ml) suppressed the invasive activity of SN12Cpm6 cells to Matrigel matrix at an inhibition rate of 72%. These results suggest that ND-2001 may be a new anti-metastatic drug against human cancer cells.

• Authors: Y Kuramitsu, J Hamada, T Tsuruoka, K Morikawa, S Naito, H Kobayashi, M Hosokawa
• Journal: Anti-cancer drugs (Anticancer Drugs) Vol. 9 Issue 8 Pg. 739-41 (Sep 1998) ISSN: 0959-4973 [Print] England
• PMID: 9823433 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• D-glucaro-delta-lactam
• Glucaric Acid

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Carcinoma, Renal Cell (pathology)
• Female
• Glucaric Acid (analogs & derivatives, pharmacology)
• Humans
• Lung Neoplasms (drug therapy, secondary)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Neoplasm Invasiveness
• Neoplasms, Experimental (drug therapy)