Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin.

Abstract

Inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice was observed in the methanol extract of rice bran and gamma-oryzanol. The active components of rice bran, sitosterol ferulate, 24-methylcholesterol ferulate, cycloartenol ferulate and 24-methylenecycloartanol ferulate inhibited markedly the TPA-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 0.2-0.3 mg/ear. Furthermore, cycloartenol ferulate markedly inhibited the tumor-promoting effect of TPA in 7,12-dimethylbenz[a]anthracene-initiated mice.

• Authors: K Yasukawa, T Akihisa, Y Kimura, T Tamura, M Takido
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 21 Issue 10 Pg. 1072-6 (Oct 1998) ISSN: 0918-6158 [Print] Japan
• PMID: 9821812 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Carcinogens
• Hypolipidemic Agents
• Phenylpropionates
• Phytosterols
• Plant Extracts
• Sterols
• Triterpenes
• 9,10-Dimethyl-1,2-benzanthracene
• Tetradecanoylphorbol Acetate
• gamma-oryzanol
• cycloartenol

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Anticarcinogenic Agents (therapeutic use)
• Carcinogens
• Cocarcinogenesis
• Dermatitis, Contact (etiology, prevention & control)
• Female
• Hypolipidemic Agents (therapeutic use)
• Mice
• Mice, Inbred ICR
• Oryza (chemistry)
• Phenylpropionates (therapeutic use)
• Phytosterols (therapeutic use)
• Plant Extracts (therapeutic use)
• Skin (drug effects)
• Skin Neoplasms (chemically induced, prevention & control)
• Sterols (therapeutic use)
• Tetradecanoylphorbol Acetate
• Triterpenes