Yolk sac tumor with a unique uniform hepatoid pattern histology.

Abstract

BACKGROUND:

Yolk sac tumors (YST) exhibit several different histological subtypes and the mechanisms of cellular differentiation and prognosis of each subtype remain unknown.

RESULTS:

We report two infants with sacrococcygeal YST; one represented a typical histological subtype and the other showed a hepatoid subtype with uniform histology. The isoform of alpha-fetoprotein (AFP) in the patient with the hepatoid pattern was examined by lectin-affinity immunoelectrophoresis and represented as a YST, but not hepatocellular, subtype. The patient with typical YST responded well to VAB-6 combination chemotherapy. However, this regimen was only partially effective to the patient with the pure hepatoid histological subtype, and an etoposide with ifosfamide and cisplatin (VIP) regimen as a salvage chemotherapy combined with complete tumor resection was useful to achieve complete remission (CR). Both of the patients have been in CR for more than four years.

• Authors: A Konno, M Kudo, T Ichihara, M Yamagami, S Horita, K Ohama, K Taketa, S Koizumi
• Journal: Acta paediatrica Japonica : Overseas edition (Acta Paediatr Jpn) Vol. 40 Issue 5 Pg. 466-9 (Oct 1998) ISSN: 0374-5600 [Print] Australia
• PMID: 9821708 (Publication Type: Case Reports, Journal Article)

Chemical References

• Protein Isoforms
• alpha-Fetoproteins

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Child, Preschool
• Combined Modality Therapy
• Endodermal Sinus Tumor (blood, pathology, therapy)
• Female
• Humans
• Infant
• Protein Isoforms
• Sacrococcygeal Region
• Salvage Therapy
• Treatment Outcome
• alpha-Fetoproteins (analysis)