Pharmacological effects of BAM-1120, a novel ergoline derivative, on central dopaminergic functions in rats.

Abstract

BAM-1120, an ergoline derivative, has been found to display a relatively high affinity for dopamine D2-like receptor subtypes in a preliminary binding study. This study investigated whether BAM-1120 acts as a dopamine receptor agonist on prolactin-secreting and motor functions. BAM-1120 suppressed hyperprolactinemia induced by pretreatment with reserpine or estradiol in female rats. Furthermore, BAM-1120 was able to shrink a prolactin-secreting pituitary tumor (prolactinoma) in the estradiol-treated female rats. BAM-1120 induced rotations contralateral to the lesion side in rats with unilateral 6-hydroxydopamine-induced lesions of nigrostriatal dopamine pathway at a dose that was at least 30-fold higher than that required for the inhibition of prolactin secretion. These findings suggest that BAM-1120 is characterized as a putative dopamine D2-like receptor agonist that possesses a preference of inhibiting prolactin secretion over activating motor behaviors.

• Authors: K Ichihara, H Kamei, K Okumura, K Mizukoshi, M Nagasaka
• Journal: Methods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 20 Issue 7 Pg. 561-6 (Sep 1998) ISSN: 0379-0355 [Print] Spain
• PMID: 9819799 (Publication Type: Journal Article)

Chemical References

• BAM 1120
• Dopamine Agents
• Dopamine Agonists
• Ergolines
• Sympatholytics
• dironyl
• Bromocriptine
• Estradiol
• Reserpine
• Lisuride
• Dopamine

Topics

• Animals
• Bromocriptine (pharmacology)
• Dopamine (physiology)
• Dopamine Agents (pharmacology)
• Dopamine Agonists (pharmacology)
• Ergolines (pharmacology)
• Estradiol
• Female
• Hyperprolactinemia (blood, chemically induced)
• Lisuride (analogs & derivatives, pharmacology)
• Male
• Rats
• Rats, Wistar
• Reserpine (pharmacology)
• Rotation
• Stereotyped Behavior (drug effects)
• Sympathectomy, Chemical
• Sympatholytics (pharmacology)