Susceptibility of penicillin-susceptible and -resistant pneumococci to CFC-222, a new fluoroquinolone.

Abstract

The in-vitro activity of 12 antibacterial agents against 98 clinical isolates of Streptococcus pneumoniae, including 54 penicillin-resistant strains, was determined by a standardized broth microdilution method. CFC-222, vancomycin and imipenem were the most active agents, with an MIC90 of 0.5 mg/L for the test strains. CFC-222 was 16-fold more potent than ciprofloxacin and ofloxacin against all strains tested, including both penicillin-susceptible and -resistant strains. The anti-pneumococcal activity of fluoroquinolones was not affected by penicillin susceptibility. These results indicate that CFC-222 is potentially useful for treating infection caused by penicillin-resistant strains of S. pneumoniae.

• Authors: J H Kim, J A Kang, Y Lee, K H Lee, J H Lee, E C Choi, B K Kim
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 42 Issue 4 Pg. 527-30 (Oct 1998) ISSN: 0305-7453 [Print] England
• PMID: 9818754 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• CFC 222
• Fluoroquinolones
• Penicillins

Topics

• Anti-Infective Agents (pharmacology)
• Fluoroquinolones
• Humans
• Microbial Sensitivity Tests
• Penicillin Resistance
• Penicillins (pharmacology)
• Streptococcus pneumoniae (drug effects, isolation & purification)