Drug resistance of Shigella strains isolated in Ankara, Turkey, 1993-1996.

Abstract

289 Shigella strains were isolated from children at the paediatrics department of Ankara University. 75% of the isolates were S. sonnei and 24.8% were S. flexneri. Each strain was tested for resistance to 9 antimicrobial agents. 79% of the isolates were resistant to streptomycin (S), 56% to tetracycline (T), 55.7% to trimethoprim-sulfamethoxazole (SXT), 27.7% to ampicillin (Am) and 19.7% to chloramphenicol (C). None of the isolates was resistant to ciprofloxacin, nalidixic acid, cephalothin, ampicillin-sulbactam and ceftriaxone. 56% of the isolates were resistant to 3 or more antimicrobial agents. The most frequent pattern of resistance of S. sonnei and S. flexneri strains was SXT, T, S (39.6%) and Am, SXT, T, S, C (48.6%), respectively (p < 0.0001). These results demonstrate that trimethoprim-sulfamethoxazole should not be used in the treatment of shigellosis.

• Authors: A D Aysev, H Guriz
• Journal: Scandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 30 Issue 4 Pg. 351-3 ( 1998) ISSN: 0036-5548 [Print] England
• PMID: 9817513 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents

Topics

• Adolescent
• Anti-Bacterial Agents (pharmacology)
• Child
• Child, Preschool
• Diarrhea (microbiology)
• Drug Resistance, Microbial
• Drug Resistance, Multiple
• Dysentery, Bacillary (microbiology)
• Feces (microbiology)
• Humans
• Infant
• Microbial Sensitivity Tests
• Shigella flexneri (drug effects, isolation & purification)
• Shigella sonnei (drug effects, isolation & purification)
• Turkey