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Clearance of persistent hepatitis B virus infection in Chinese bone marrow transplant recipients whose donors were anti-hepatitis B core- and anti-hepatitis B surface antibody-positive.

AbstractThirteen hepatitis B surface antigen-positive Chinese patients who received hepatitis B surface antibody-positive marrow (hepatitis B core antibody-positive or -negative: 6 and 7, respectively) via allogeneic bone marrow transplantation (BMT) were studied. After BMT, 4 recipients had serologic clearance of hepatitis B surface antigen from hepatitis B core antibody-positive marrow, but none of the recipients of hepatitis B core antibody-negative marrow had serologic clearance (P=.02). There was no significant difference in the donors' hepatitis B surface antibody titer before BMT for patients with or without serologic clearance of hepatitis B surface antigen (2255.2+/-4244.0 vs. 854.2+/-2306.7 mIU/mL; P=not significant). Adoptive immunity clearance of hepatitis B surface antigen was favored by hepatitis B core antibody positive-donor marrow and was not related to donor pre-BMT hepatitis B surface antibody titer.
AuthorsG K Lau, R Liang, C K Lee, S T Yuen, J Hou, W L Lim, R Williams (Affiliation: Divisions of Gastroenterology and Hepatology, Queen Mary Hospital, Hong Hong, SAR, China.)
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 178 Issue 6 Pg. 1585-91 (Dec 1998) ISSN: 0022-1899 [Print] UNITED STATES
PMID9815208 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA, Viral
  • Hepatitis B Antibodies
  • Hepatitis B Core Antigens
  • Hepatitis B Surface Antigens
  • Hepatitis B e Antigens
Topics
  • Adolescent
  • Adult
  • Bone Marrow (immunology)
  • Bone Marrow Transplantation (adverse effects, immunology)
  • Child
  • China (ethnology)
  • DNA, Viral (blood)
  • Female
  • Hepatitis B (immunology, transmission)
  • Hepatitis B Antibodies (blood)
  • Hepatitis B Core Antigens (analysis, immunology)
  • Hepatitis B Surface Antigens (analysis, blood, immunology)
  • Hepatitis B e Antigens (analysis)
  • Hepatitis B virus (isolation & purification)
  • Hong Kong
  • Humans
  • Liver Diseases (etiology)
  • Living Donors
  • Male
  • Middle Aged
  • Postoperative Complications
  • Retrospective Studies
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transplantation, Homologous

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