Abstract | OBJECTIVE: DESIGN: A prospective, randomized, blinded trial. SETTING: The emergency department of a large academic children's hospital. PATIENTS: Children one year of age or older with a laceration 5 cm or less in length on or near a mucous membrane. INTERVENTIONS: Forty patients were randomly assigned one of the two local anesthetics, with 20 patients in each treatment group. OUTCOME MEASURES:
Pain felt during suturing was scored by suture technicians, research assistants, a videotape reviewer, parents, and patients five years of age and older using a visual analog scale (VAS). RESULTS: There was no statistically significant difference in performance between topical Prilophen and lidocaine infiltration when VAS pain scores of research assistants, parents, and patients were compared. However, lidocaine infiltration performed significantly better than topical Prilophen when comparing VAS scores of suture technicians (P = 0.003) and the videotape reviewer (P = 0.02). When power analyses were performed using alpha = 0.05 and beta = 0.20, it was possible to detect a difference of 2 units for VAS scores of suture technicians, 2 VAS units for research assistants, 3 VAS units for the videotape reviewer and parents, and 7 VAS units for patients. There were no wound healing or other complications. CONCLUSIONS:
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Authors | G A Smith, S D Strausbaugh, C Harbeck-Weber, D M Cohen, B J Shields, J D Powers |
Journal | Pediatric emergency care
(Pediatr Emerg Care)
Vol. 14
Issue 5
Pg. 324-8
(Oct 1998)
ISSN: 0749-5161 [Print] United States |
PMID | 9814396
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Local
- Drug Combinations
- Vasoconstrictor Agents
- prilocaine-phenylephrine
- Prilocaine
- Phenylephrine
- Lidocaine
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Topics |
- Adolescent
- Anesthesia, Local
- Anesthetics, Local
(administration & dosage)
- Child
- Child, Preschool
- Contraindications
- Drug Combinations
- Female
- Humans
- Infant
- Lidocaine
- Male
- Mucous Membrane
(injuries)
- Phenylephrine
(administration & dosage)
- Prilocaine
(administration & dosage)
- Prospective Studies
- Vasoconstrictor Agents
(administration & dosage)
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