| Abstract | OBJECTIVE: To asses the efficacy of combination therapy of glibenclamide and Kelening in treating the non-insulin dependent diabetes mellitus (NIDDM). METHODS: Sixty-five patients with NIDDM were randomly divided into two groups. One group was treated with both glibenclamide and Kelening, the other with glibenclamide alone. RESULTS: After treatment for 12 weeks, the levels of fasting blood glucose (FBG), postprandial blood glucose (PBG) and HBAIC were reduced significantly in glibenclamide-Kelening group. In both groups, the degree dropped of the levels of FBG were almost the same, but the levels of PBG and HBAIC in glibenclamide-Kelening group were reduced more significantly than those in glibenclamide group, and the incidence of hyperinsulinemia had dropped considerably. CONCLUSION: Glibenclamide in combination with Kelening in the treatment of NIDDM is more effective and less toxic, and the combination may reduce the dosage of glibenclamide in NIDDM. |
| Authors | P Zhou
(Affiliation: Department of Endocrinology, Gulou Hospital, Nanjing.)
|
| Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 17
Issue 1
Pg. 29-31
(Jan 1997)
ISSN: 1003-5370 CHINA |
| PMID | 9812648
(Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
|
| Chemical References |
- Blood Glucose
- Drug Combinations
- Drugs, Chinese Herbal
- Hemoglobin A, Glycosylated
- Hypoglycemic Agents
- Glyburide
- Insulin
|
| Topics |
- Adult
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Drug Combinations
- Drugs, Chinese Herbal
(therapeutic use)
- Female
- Glyburide
(therapeutic use)
- Hemoglobin A, Glycosylated
(metabolism)
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Insulin
(blood)
- Male
- Middle Aged
|
