Excretion of triethyllead, diethyllead and inorganic lead in rabbits after injection of triethyl neopentoxy lead.

Abstract

Triethyl neopentoxy lead (TEneoPOL: (C2H5)3Pb [OCH2C(CH3)3] liquid) was administered to rabbits in a single dose of 10 mg/kg body weight (5.4 mg Pb/kg body weight), and the urinary and fecal excretions of lead were measured to determine the fate of this triethyllead derivative. About 4% of the administered amount of was excreted into the urine during the 7 days after the injection; and about 68%, into the feces. In other words, the fecal excretion of total lead was about 17 times as great as the urinary excretion. About 85% of the urinary excretion of total lead was composed of diethyllead (Et2Pb2+), and about 92% of the fecal excretion consisted of inorganic lead (Pb2+). The major chemical species of lead excreted in the urine was Et2Pb2+, while the major species excreted in the feces was Pb2+. These results were similar to those of administration of tetraethyllead (Et4Pb) to rabbits. One of the 7 rabbits died on the day following the injection, and TEneoPOL, a triethyllead derivative, proved to be no less toxic than Et4Pb. However, this compound is immediately hydrolyzed by the ambient moisture to form a white solid compound, so that it is not accompanied by as great a risk of airway exposure as Et4Pb.

• Authors: F Arai, H Yamauchi, K Chiba, K Yoshida
• Journal: Industrial health (Ind Health) Vol. 36 Issue 4 Pg. 331-6 (Oct 1998) ISSN: 0019-8366 [Print] Japan
• PMID: 9810146 (Publication Type: Journal Article)

Chemical References

• Organometallic Compounds
• diethyllead
• Lead
• triethyllead

Topics

• Animals
• Feces (chemistry)
• Injections, Intravenous
• Kinetics
• Lead (pharmacokinetics, urine)
• Organometallic Compounds (pharmacokinetics, urine)
• Rabbits
• Urine (chemistry)