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Inhibition of cytokine production and arachidonic acid metabolism by eucalyptol (1.8-cineole) in human blood monocytes in vitro.

Abstract
Cineole (eucalyptol) is the isolated active agent of eucalyptus oil. Traditionally, it is recommended for treating the symptoms of airway diseases exacerbated by infection. We have examined the inhibitory effect of 1.8-cineole on LPS-and IL1beta-stimulated mediator production by human monocytes in vitro. For the first time, we report on a dose-dependent and highly significant inhibition of production of tumor necrosis factor-alpha, interleukin-1beta, leukotriene B4 and thromboxane B2 by 1.8-cineole. In summary, this is the first report on a new mechanism of action of monoterpenes suggesting 1.8-cineole as a strong inhibitor of cytokines that might be suitable for longterm treatment of airway inflammation in bronchial asthma and other steroid-sensitive disorders.
AuthorsU R Juergens, M Stöber, H Vetter
JournalEuropean journal of medical research (Eur J Med Res) Vol. 3 Issue 11 Pg. 508-10 (Nov 17 1998) ISSN: 0949-2321 [Print] England
PMID9810029 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclohexanols
  • Cytokines
  • Inflammation Mediators
  • Interleukin-1
  • Lipopolysaccharides
  • Monoterpenes
  • Terpenes
  • Tumor Necrosis Factor-alpha
  • Menthol
  • Leukotriene B4
  • Arachidonic Acid
  • Thromboxane B2
  • Eucalyptol
Topics
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Arachidonic Acid (metabolism)
  • Asthma (drug therapy)
  • Cyclohexanols
  • Cytokines (biosynthesis)
  • Eucalyptol
  • Female
  • Humans
  • In Vitro Techniques
  • Inflammation (drug therapy)
  • Inflammation Mediators (metabolism)
  • Interleukin-1 (biosynthesis, pharmacology)
  • Leukotriene B4 (biosynthesis)
  • Lipopolysaccharides (pharmacology)
  • Male
  • Menthol (analogs & derivatives, pharmacology)
  • Monocytes (drug effects, metabolism)
  • Monoterpenes
  • Respiratory Tract Diseases (drug therapy)
  • Terpenes
  • Thromboxane B2 (biosynthesis)
  • Tumor Necrosis Factor-alpha (biosynthesis)

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