Abstract | BACKGROUND/PURPOSE: Some malignant pediatric tumors express the polysialylated form of the neural cell adhesion molecule ( PSA-NCAM), which normally becomes restricted to a few regions of neural plasticity and regenerating nerve tissue after embryogenesis. Recently, serum concentrations of polysialylated NCAM have been shown to be tumor associated in children with rhabdomyosarcoma and neuroblastoma. This study was undertaken to evaluate polysialylated NCAM as a marker helpful in distinguishing between various embryonal tumors and other lesions suspicious of a malignancy. METHODS: RESULTS: CONCLUSION:
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Authors | S Glüer, C Schelp, R Gerardy-Schahn, D von Schweinitz |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 33
Issue 10
Pg. 1516-20
(Oct 1998)
ISSN: 0022-3468 [Print] United States |
PMID | 9802804
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Neural Cell Adhesion Molecule L1
- Neural Cell Adhesion Molecules
- Sialic Acids
- polysialyl neural cell adhesion molecule
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Topics |
- Adolescent
- Adrenal Gland Neoplasms
(diagnosis, metabolism)
- Biomarkers, Tumor
(blood, metabolism)
- Child
- Child, Preschool
- Diagnosis, Differential
- Female
- Humans
- Immunohistochemistry
- Infant
- Kidney Neoplasms
(diagnosis, metabolism)
- Luminescent Measurements
- Male
- Neural Cell Adhesion Molecule L1
- Neural Cell Adhesion Molecules
(blood, metabolism)
- Neuroblastoma
(diagnosis, metabolism)
- Pleural Effusion, Malignant
(diagnosis, metabolism)
- Rhabdomyosarcoma
(diagnosis, metabolism)
- Sialic Acids
(blood, metabolism)
- Thoracic Neoplasms
(diagnosis, metabolism)
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