Abstract | BACKGROUND: Exposure to allergens early in life influences the development of allergen-specific immune responses. In animal models, the development of tolerance to proteins delivered to the gastrointestinal and the respiratory mucosa is influenced by age and genetic background. Late introduction of cow's milk in infants is associated with slower increase and lower peak IgG antibody responses to milk during early childhood, but the long-term effects have not been investigated, nor is the relation to atopic disease later in life clear. OBJECTIVE: The purpose of this study was to investigate the development of IgG subclass antibodies to beta-lactoglobulin in relation to early exposure to cow's milk, atopic heredity, and the development of atopic disease. METHODS: RESULTS: CONCLUSIONS:
IgG subclass antibody levels to milk peak during early infancy, with particularly high levels in children with atopic dermatitis, and decline thereafter. Exposure to cow's milk during early infancy has long-lasting effects on the humoral antigen-specific responses, indicating less effective tolerance-inducing mechanisms in the intestinal mucosa during the first months of life.
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Authors | M C Jenmalm, B Björkstén |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 102
Issue 4 Pt 1
Pg. 671-8
(Oct 1998)
ISSN: 0091-6749 [Print] United States |
PMID | 9802378
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulin G
- Lactoglobulins
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Topics |
- Animals
- Child
- Child, Preschool
- Cohort Studies
- Female
- Humans
- Hypersensitivity
(epidemiology, genetics, immunology)
- Immunoglobulin G
(analysis)
- Incidence
- Infant
- Kinetics
- Lactoglobulins
(immunology)
- Male
- Milk
(immunology)
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