[New therapies in type 2 diabetes].

Abstract

The progress of knowledge relating to non-insulin-dependent diabetes mellitus (NIDDM) is associated with new therapeutic developments. Their different respective targets allow to classify them in drugs stimulating insulin secretion (glimepiride, repaglinide, glucagon-like peptide 1), medications reducing insulin resistance (thiazolidinediones) or in insulinmimetic agents (vanadium). Alpha glucosidase inhibitors, available in France since 1993, constitute another therapeutic approach, reducing postprandial hyperglycemia by delaying the digestion of complex carbohydrates. These new medications, safer and sometimes effective in a single daily administration, represent an alternative to classic oral antidiabetic agents allowing therapeutic combinations and a more global management of NIDDM.

• Authors: N Neyrolles, J F Blicklé, J M Brogard
• Journal: Annales d'endocrinologie (Ann Endocrinol (Paris)) Vol. 59 Issue 2 Pg. 67-77 (Jul 1998) ISSN: 0003-4266 [Print] France
• Vernacular Title: Nouvelles thérapies dans le diabète de type 2.
• PMID: 9789590 (Publication Type: Journal Article, Review)

Chemical References

• Enzyme Inhibitors
• Glycoside Hydrolase Inhibitors
• Insulin
• Vanadium

Topics

• Diabetes Mellitus, Type 2 (drug therapy)
• Enzyme Inhibitors (therapeutic use)
• Glycoside Hydrolase Inhibitors
• Humans
• Insulin (metabolism)
• Insulin Resistance
• Insulin Secretion
• Secretory Rate (drug effects)
• Structure-Activity Relationship
• Vanadium (therapeutic use)