[Drug-induced gingival hyperplasia].

Abstract

A case report is presented, which describes a kidney-transplant recipient medicated simultaneously with both cyclosporin A and nifedipine and who developed an extreme form of gingival hyperplasia. Repeated dental-surgical treatments provided only temporary regression of the gingival overgrowth, however, after discontinuation of the calcium channel blocker there was a significant improvement of the hyperplasia that no longer required specific dental treatment. The prevalence and mechanisms of this side effect in solid-organ transplant recipients on cyclosporin therapy is discussed. Treatment consists in the discontinuation of potentiating factors like calcium channel blockers and possibly also a dose reduction of cyclosporin, which together may support or reduce the need of dental-surgical procedures.

• Authors: F Nohl, P Ferrari
• Journal: Therapeutische Umschau. Revue therapeutique (Ther Umsch) Vol. 55 Issue 9 Pg. 573-5 (Sep 1998) ISSN: 0040-5930 [Print] Switzerland
• Vernacular Title: Medikamenteninduzierte Gingivahyperplasie.
• PMID: 9789475 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antihypertensive Agents
• Calcium Channel Blockers
• Immunosuppressive Agents
• Cyclosporine
• Nifedipine

Topics

• Adult
• Antihypertensive Agents (administration & dosage, adverse effects)
• Calcium Channel Blockers (administration & dosage, adverse effects)
• Cyclosporine (administration & dosage, adverse effects)
• Drug Therapy, Combination
• Female
• Gingival Hyperplasia (chemically induced)
• Humans
• Immunosuppressive Agents (administration & dosage, adverse effects)
• Kidney Transplantation
• Nifedipine (administration & dosage, adverse effects)