Abstract |
The antigenic and immunogenic properties of the R-form lipopolysaccharides (R-LPS) of Pseudomonas aeruginosa, Salmonella minnesota, Escherichia coli and Shigella were studied. The results of the study revealed the existence of antigenic relationship between P.aeruginosa R-LPS and R-LPS Escherichia and Shigella. In serological tests no antigenic relationship between P. aeruginosa R-LPS and Salmonella R-LPS was revealed, but as shown in earlier experiments of the protection of mice, Re-glycolipid stimulated protective immunity against Pseudomonas infection in the animals. On the basis of R-LPS obtained from selected P. aeruginosa and Salmonella strains a vaccine was prepared which proved to be effective against infection caused by P. aeruginosa S-strain in experiments on mice. The vaccine induced protection in 40-100% of immunized mice, depending on the scheme of immunization. The vaccine may probably be effective against infections caused by other gram-negative bacteria.
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Authors | E S Stanislavskiĭ, T A Makarenko, E V Kholodkova, C Lugowski |
Journal | Zhurnal mikrobiologii, epidemiologii i immunobiologii
(Zh Mikrobiol Epidemiol Immunobiol)
1998 Jul-Aug
Issue 4
Pg. 52-6
ISSN: 0372-9311 [Print] Russia (Federation) |
Vernacular Title | Antigennyĭ analiz i protektivnye svoĭstva lipopolisakharidov R-form nekotorykh gramotritsatel'nykh bakteriĭ. |
PMID | 9783402
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Bacterial
- Antigens, Bacterial
- Bacterial Vaccines
- Lipopolysaccharides
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Topics |
- Animals
- Antibodies, Bacterial
(blood)
- Antigens, Bacterial
(analysis, immunology)
- Bacterial Vaccines
(immunology)
- Dose-Response Relationship, Immunologic
- Escherichia coli
(immunology)
- Gram-Negative Bacteria
(immunology)
- Gram-Negative Bacterial Infections
(prevention & control)
- Immunization
- Lipopolysaccharides
(immunology)
- Mice
- Mutation
(immunology)
- Plesiomonas
(immunology)
- Pseudomonas aeruginosa
(immunology)
- Salmonella
(immunology)
- Shigella sonnei
(immunology)
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