[An antigenic analysis and the protective properties of the R-form lipopolysaccharides of gram-negative bacteria].

Abstract

The antigenic and immunogenic properties of the R-form lipopolysaccharides (R-LPS) of Pseudomonas aeruginosa, Salmonella minnesota, Escherichia coli and Shigella were studied. The results of the study revealed the existence of antigenic relationship between P.aeruginosa R-LPS and R-LPS Escherichia and Shigella. In serological tests no antigenic relationship between P. aeruginosa R-LPS and Salmonella R-LPS was revealed, but as shown in earlier experiments of the protection of mice, Re-glycolipid stimulated protective immunity against Pseudomonas infection in the animals. On the basis of R-LPS obtained from selected P. aeruginosa and Salmonella strains a vaccine was prepared which proved to be effective against infection caused by P. aeruginosa S-strain in experiments on mice. The vaccine induced protection in 40-100% of immunized mice, depending on the scheme of immunization. The vaccine may probably be effective against infections caused by other gram-negative bacteria.

• Authors: E S Stanislavskiĭ, T A Makarenko, E V Kholodkova, C Lugowski
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) 1998 Jul-Aug Issue 4 Pg. 52-6 ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Antigennyĭ analiz i protektivnye svoĭstva lipopolisakharidov R-form nekotorykh gramotritsatel'nykh bakteriĭ.
• PMID: 9783402 (Publication Type: Journal Article)

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Bacterial Vaccines
• Lipopolysaccharides

Topics

• Animals
• Antibodies, Bacterial (blood)
• Antigens, Bacterial (analysis, immunology)
• Bacterial Vaccines (immunology)
• Dose-Response Relationship, Immunologic
• Escherichia coli (immunology)
• Gram-Negative Bacteria (immunology)
• Gram-Negative Bacterial Infections (prevention & control)
• Immunization
• Lipopolysaccharides (immunology)
• Mice
• Mutation (immunology)
• Plesiomonas (immunology)
• Pseudomonas aeruginosa (immunology)
• Salmonella (immunology)
• Shigella sonnei (immunology)