Myofibrillar protein pattern in experimental myotonia in rats.

Abstract

Experimental myotonia was induced in rats by long-term administration of 20,25-diazacholesterol. Electrophysiological, morphological and biochemical investigations were carried out on m. soleus, m. extensor digitorum longus and m. gastrocnemius. The effect of 20,25-diazacholesterol administration on myofibrillar proteins was studied and a significant rise in the concentration of a protein presumed to be alpha-actinin was demonstrated in m. gastrocnemius. A change of the same character, not statistically significant, was observed in the m. extensor digitorum longus.

• Authors: I Niebrój-Dobosz, H Kwieciński, A Kamińska
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 29 Issue 2-4 Pg. 241-7 (Oct 1976) ISSN: 0022-510X [Print] Netherlands
• PMID: 978209 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Actins
• Muscle Proteins
• Actinin
• Myosins

Topics

• Actinin (analysis)
• Actins (analysis)
• Animals
• Disease Models, Animal
• Male
• Muscle Proteins (analysis)
• Muscles (pathology)
• Myofibrils (analysis)
• Myosins (analysis)
• Myotonia (metabolism, pathology)
• Rats