Efficacy of oral administration of itraconazole to cats with dermatophytosis caused by Microsporum canis.

Abstract

OBJECTIVE:

To determine efficacy of orally administered itraconazole in cats with dermatophytosis caused by Microsporum canis.

DESIGN:

Uncontrolled clinical trial.

ANIMALS:

15 cats with dermatophytosis caused by M canis.

PROCEDURE:

All cats were treated with itraconazole (1.5 to 3.0 mg/kg [0.7 to 1.4 mg/lb] of body weight, PO, q 24 h, for 15 days). Six cats had been treated with griseofulvin (10 mg/kg [4.5 mg/lb], PO, q 24 h) during a 60-day period, but their clinical condition had not improved. Five cats treated at the highest dosage of itraconazole vomited or became anorectic. Consequently, dosages were progressively decreased for each cat until adverse effects were not evident. After treatment, samples of hair were submitted for fungal cultures, and if appropriate, treatment was repeated when culture results were positive.

RESULTS:

8 cats treated with itraconazole recovered completely, as indicated by resolution of lesions and negative results of fungal cultures. Six of these 8 cats received a single 15-day course of treatment, whereas the remaining 2 cats needed prolonged treatment (two 15-day courses of treatment and three 15-day courses of treatment). In 4 other cats that became clinically normal, M canis was isolated from hair samples obtained at the completion of treatment, even though only 1 colony or a small number of colonies was isolated. In the other 3 cats, itraconazole did not cause clinical improvement, and culture results remained positive.

CLINICAL IMPLICATIONS:

Oral administration of itraconazole at dosages of 1.5 to 3.0 mg/kg may be useful for the treatment of cats with dermatophytosis attributable to M canis infections.

• Authors: F Mancianti, F Pedonese, C Zullino
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 213 Issue 7 Pg. 993-5 (Oct 01 1998) ISSN: 0003-1488 [Print] United States
• PMID: 9776995 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antifungal Agents
• Itraconazole
• Griseofulvin

Topics

• Administration, Oral
• Animals
• Antifungal Agents (administration & dosage, adverse effects, therapeutic use)
• Cat Diseases (drug therapy)
• Cats
• Dermatomycoses (drug therapy, veterinary)
• Dose-Response Relationship, Drug
• Female
• Griseofulvin (therapeutic use)
• Itraconazole (administration & dosage, adverse effects, therapeutic use)
• Male
• Microsporum (isolation & purification)