Abstract |
The specific dopamine uptake inhibitor, GBR 12783 was tested on the retention performance of a one-trial passive avoidance test. For a moderate electric shock intensity, GBR 12783 (10 mg/kg), injected before acquisition session, improved retention performance. Scopolamine (0.125-0.5 mg/kg) completely blocked the promnesic effect of GBR 12783. Moreover, GBR 12783 increased hippocampal acetylcholine release in vivo. These data suggest that the promnesic effect of GBR 12783 is mediated by an increase in the septo-hippocampal cholinergic transmission.
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Authors | K Nail-Boucherie, N Dourmap, R Jaffard, J Costentin |
Journal | Brain research. Cognitive brain research
(Brain Res Cogn Brain Res)
Vol. 7
Issue 2
Pg. 203-5
(Oct 1998)
ISSN: 0926-6410 [Print] Netherlands |
PMID | 9774732
(Publication Type: Journal Article)
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Copyright | Copyright 1998 Elsevier Science B.V. |
Chemical References |
- Dopamine Uptake Inhibitors
- Muscarinic Antagonists
- Piperazines
- Receptors, Muscarinic
- 1-(2-(diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine
- Scopolamine
- Acetylcholine
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Topics |
- Acetylcholine
(metabolism)
- Animals
- Avoidance Learning
(drug effects)
- Behavior, Animal
(drug effects)
- Dopamine Uptake Inhibitors
(pharmacology)
- Hippocampus
(chemistry, metabolism)
- Male
- Microdialysis
- Muscarinic Antagonists
(pharmacology)
- Piperazines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptors, Muscarinic
(physiology)
- Scopolamine
(pharmacology)
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