Abstract | OBJECTIVE: METHODS: RESULTS: Seven of 11 patients achieved remission rapidly, whereas a modest improvement was noted in two. Only two patients required an early and one a delayed colectomy. Moreover, a rectovaginal fistula closure in a case of Crohn's disease and an improvement of pouchitis was observed. A tapering to low dose steroids was possible during oral tacrolimus therapy in all nine responders and remission was maintained in five of them (mean follow-up 9.2 months). The drug was well tolerated and side effects were managed conservatively. CONCLUSION:
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Authors | K Fellermann, D Ludwig, M Stahl, T David-Walek, E F Stange |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 93
Issue 10
Pg. 1860-6
(Oct 1998)
ISSN: 0002-9270 [Print] United States |
PMID | 9772045
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Immunosuppressive Agents
- Steroids
- Cyclosporine
- Tacrolimus
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Topics |
- Adolescent
- Adult
- Aged
- Anti-Inflammatory Agents
(therapeutic use)
- Colitis, Ulcerative
(drug therapy)
- Crohn Disease
(drug therapy)
- Cyclosporine
(therapeutic use)
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Pilot Projects
- Prospective Studies
- Remission Induction
- Steroids
- Tacrolimus
(administration & dosage, therapeutic use)
- Time Factors
- Treatment Failure
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