Abstract | AIM: Evaluation of effectiveness of hypolipidemic action of probucol in doses 500 and 1000 mg/day and comparison of probucol blood concentrations on the treatment month 3 and 6. MATERIALS AND METHODS:
Probucol (Akrikhin, Russia) was given to 41 patients with primary hypercholesterolemia in a dose 500 mg/day. 3 months later the patients were divided into two groups. Group 1 patients exhibited a > 10% decrease in cholesterol levels and continued to take probucol in the dose 500 mg/day. Group 2 patients were crossed over to higher cholesterol dose--up to 1000 mg/day. Lipids levels were measured by enzyme tests, apoproteins--by immunoturbidimetry and immunodiffusion, probucol concentrations--by high-performance liquid chromatography. RESULTS: After 3 months of treatment, cholesterol lowered by 14.3 and 9.2% in groups 1 and 2, respectively. After 6 months, by 19.7 and 12.9%, respectively. Probucol concentrations in blood were higher after 6 months of treatment than after 3 months in both groups. No significant differences existed between the groups by probucol concentrations in 3 and 6 months. CONCLUSION:
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Authors | M G Tvorogova, V P Lupanov, E Iu Nuraliev, T M Zaĭtseva, V V Kukharchuk, V N Titov |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 70
Issue 8
Pg. 17-21
( 1998)
ISSN: 0040-3660 [Print] Russia (Federation) |
Vernacular Title | Sopostavlenie gipolipidemicheskogo deĭstviia probukola v doze 500 i 1000 mg/sut pri umerennoĭ giperlipoproteidemii. |
PMID | 9770737
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Apolipoproteins
- Hypolipidemic Agents
- Lipids
- Probucol
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Topics |
- Adult
- Aged
- Apolipoproteins
(blood)
- Combined Modality Therapy
- Diet, Fat-Restricted
- Dose-Response Relationship, Drug
- Drug Evaluation
- Female
- Humans
- Hyperlipoproteinemias
(blood, diet therapy, drug therapy)
- Hypolipidemic Agents
(administration & dosage, blood)
- Lipids
(blood)
- Male
- Middle Aged
- Probucol
(administration & dosage, blood)
- Time Factors
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