Sneddon was the first one to describe the association of cerebrovascular insult (CVI) and skin changes by
livedo reticularis type. Angiography of this patient revealed normal brain blood vessels, occlusive changes or the changes similar to those in
moya-moya disease. Computed tomography (CT) of the brain most frequently revealed ischemic lesions and/or diffuse
atrophy of the brain, although the normal finding was also possible. Considering the frequent finding of the increased titer of
anticardiolipin antibodies (ACA) in those patients, those
antibodies could be the most important in the pathogenesis of Sneddon's syndrome. A case of female patient, aged 66 years, with
livedo reticularis and recurrent CVI was presented in this study. By panangiography were revealed normal blood vessels of the brain, by scintigraphy two ischemic lesions and by CT ischemic lesions with pronounced cortical and subcortical reductive changes. In laboratory findings were observed increased immunocomplexes and the presence of lupus-like
anticoagulants, increased ACA titer, the increase in
fibrinogen value associated with increased ESR. The result of bone marrow examination was normal, while the borreliosis test was negative.
Vasculitis was excluded by skin biopsy. Solid improvement was noticed after the immunosuppresive
therapy was administered, but in the last
disease exacerbation with new CVI, the outcome was lethal 3 years since the disease onset.