Neisseria gonorrhoeae contains multiple copies of a gene that may encode a site-specific recombinase and is associated with DNA rearrangements.

Abstract

A 960-bp ORF potentially encoding a site-specific recombinase has been cloned from Neisseria gonorrhoeae MS11-A. This ORF was designated pivNg on the basis of similarity of the deduced amino acid sequence to the Piv proteins of Moraxella spp. that are site-specific invertases. Southern hybridization and sequence analysis revealed that there were multiple copies of pivNg sequence within the genomes of N. gonorrhoeae strains tested, but not in several other neisserial species. Southern hybridization and sequence analysis further suggested that pivNg sequences may be associated with genomic rearrangements.

• Authors: C S Carrick, J A Fyfe, J K Davies
• Journal: Gene (Gene) Vol. 220 Issue 1-2 Pg. 21-9 (Oct 05 1998) ISSN: 0378-1119 [Print] Netherlands
• PMID: 9767087 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Bacterial
• Recombinases
• DNA Nucleotidyltransferases
• Integrases
• integron integrase IntI1

Topics

• Amino Acid Sequence
• Base Sequence
• Chromosome Inversion
• DNA Nucleotidyltransferases (genetics, metabolism)
• DNA, Bacterial (genetics, metabolism)
• Gene Dosage
• Genes, Bacterial
• Integrases
• Molecular Sequence Data
• Multigene Family (genetics)
• Neisseria gonorrhoeae (genetics)
• Recombinases
• Sequence Homology, Amino Acid