The effect of phenobarbital on patients with Dubin-Johnson syndrome.

Abstract

11 patients with jaundice of Dubin-Johnson type were treated for 2 weeks with phenobarbital. Serum bilirubin diminished and hepatic clearance of sulfobromophthalein was variably enhanced; other measures of hepatic function were not significantly changed during therapy.

• Authors: C Merdler, M Burke, M Shani, S Felner, I Lurie
• Journal: Digestion (Digestion) Vol. 14 Issue 5-6 Pg. 394-9 ( 1976) ISSN: 0012-2823 [Print] Switzerland
• PMID: 976623 (Publication Type: Journal Article)

Chemical References

• Sulfobromophthalein
• Bilirubin
• Phenobarbital

Topics

• Adolescent
• Adult
• Bilirubin (blood)
• Drug Evaluation
• Female
• Humans
• Jaundice, Chronic Idiopathic (blood, drug therapy, physiopathology)
• Liver (physiopathology)
• Male
• Middle Aged
• Phenobarbital (therapeutic use)
• Sulfobromophthalein