Abstract | BACKGROUNDS/AIMS: METHODS: Sprague-Dawley rats were used in the experimental model of obstructive jaundice. PEG-BOX or an equivalent amount of PEG alone was intravenously injected into the animals and sampling of blood and urine, and liver harvesting were done sequentially after bile duct ligation. RESULTS: Conventional liver function tests showed no difference between PEG-BOX and control groups. However, bilirubin concentrations in the peripheral blood and liver tissue specimens markedly decreased, and the hepatic energy charge significantly increased in the PEG-BOX group as compared to controls. The blood concentration of bile acid was lower, but its urinary excretion was higher in the PEG-BOX group than in the control group. In vitro incubation of PEG-BOX with serum from rats with obstructive jaundice decreased the concentration of bilirubin but not that of bile acid. The urinary levels of prostaglandin E2 and the thromboxane B2/6-keto- prostaglandin Fla ratio were significantly lower in the PEG-BOX group than in the control group. CONCLUSIONS:
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Authors | T Kamisako, S Miyawaki, E C Gabazza, T Ishihara, A Kamei, N Kawamura, Y Adachi |
Journal | Journal of hepatology
(J Hepatol)
Vol. 29
Issue 3
Pg. 424-9
(Sep 1998)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 9764989
(Publication Type: Journal Article)
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Chemical References |
- Prostaglandins
- Polyethylene Glycols
- Oxidoreductases
- Oxidoreductases Acting on CH-CH Group Donors
- bilirubin oxidase
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Topics |
- Animals
- Cholestasis
(drug therapy, metabolism)
- Drug Evaluation, Preclinical
- Energy Metabolism
(drug effects)
- Hepatorenal Syndrome
(physiopathology)
- Hyperbilirubinemia
(physiopathology)
- Liver
(drug effects)
- Male
- Oxidoreductases
(chemistry, therapeutic use)
- Oxidoreductases Acting on CH-CH Group Donors
- Polyethylene Glycols
(chemistry)
- Prostaglandins
(urine)
- Rats
- Rats, Sprague-Dawley
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