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In vivo and in vitro antiinflammatory activity of saikosaponins.

Abstract
Buddlejasaponin I and saikosaponin 1 and 2, biologically active compounds from Scrophularia scorodonia and Bupleurum rigidum respectively, exert potent in vivo antiinflammatory effects on mouse ear edema induced by phorbol myristate acetate (PMA). The effects of these compounds on swelling and other inflammatory parameters are described. In screening for in vitro effects of saikosaponins on cellular systems generating cyclooxygenase (COX) and lipoxygenase (LOX) metabolites, we observed that most saikosaponins showed a significant effect. The action is more marked on LOX metabolite LTC4. Our data support the inhibition of arachidonic acid metabolism as one of the biochemical mechanisms that might be the rationale for the putative antiphlogistic activity of these saikosaponins.
AuthorsP Bermejo Benito, M J Abad Martínez, A M Silván Sen, A Sanz Gómez, L Fernández Matellano, S Sánchez Contreras, A M Díaz Lanza
JournalLife sciences (Life Sci) Vol. 63 Issue 13 Pg. 1147-56 ( 1998) ISSN: 0024-3205 [Print] Netherlands
PMID9763210 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Infective Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Plant Extracts
  • Sapogenins
  • Saponins
  • buddlejasaponin
  • Leukotriene C4
  • Oleanolic Acid
  • Dinoprostone
  • Tetradecanoylphorbol Acetate
  • saikosaponin D
Topics
  • Animals
  • Anti-Infective Agents (pharmacology)
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Carbohydrate Sequence
  • Cell Survival (drug effects)
  • Cells, Cultured
  • Dinoprostone (biosynthesis, metabolism)
  • Ear, External (drug effects)
  • Edema (chemically induced, drug therapy)
  • Female
  • Humans
  • Leukotriene C4 (biosynthesis, metabolism)
  • Macrophages, Peritoneal (drug effects, metabolism)
  • Male
  • Mice
  • Molecular Sequence Data
  • Oleanolic Acid (analogs & derivatives)
  • Plant Extracts (pharmacology)
  • Plants, Medicinal (chemistry)
  • Sapogenins (pharmacology)
  • Saponins (pharmacology)
  • Tetradecanoylphorbol Acetate (pharmacology)

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