Effects of delta-sleep-inducing peptide in cerebral ischemia in rats.

Abstract

Experimental studies were carried out to investigate the neuroprotective effects of delta sleep-inducing peptide in animals with cerebral ischemia induced by bilateral compression of both carotid arteries, and to compare the efficacy of this peptide with that of MK-801. These studies led to the conclusion that the peptide had pronounced anti-ischemic effects, which were evident within 24 h and consisted of reductions in the severity of postural abnormalities in rats with bilateral cerebral ischemia, along with a reduction in lethality. Comparison of the efficacies of peptide and MK-801 showed the peptide to have the greater neuroprotective effect. These results are regarded as providing an experimental basis for using the peptide as a therapeutic agent in patients with stroke.

• Authors: A A Shandra, L S Godlevskii, A I Brusentsov, R S Vast'yanov, V A Karlyuga, A F Dzygal, B Nikel
• Journal: Neuroscience and behavioral physiology (Neurosci Behav Physiol) 1998 Jul-Aug Vol. 28 Issue 4 Pg. 443-6 ISSN: 0097-0549 [Print] United States
• PMID: 9762721 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Excitatory Amino Acid Antagonists
• Delta Sleep-Inducing Peptide
• Dizocilpine Maleate

Topics

• Animals
• Carotid Artery Diseases (complications, physiopathology)
• Carotid Artery, Common (physiopathology)
• Delta Sleep-Inducing Peptide (therapeutic use)
• Dizocilpine Maleate (therapeutic use)
• Excitatory Amino Acid Antagonists (therapeutic use)
• Ischemic Attack, Transient (drug therapy, etiology, physiopathology)
• Male
• Pain Measurement (drug effects)
• Posture (physiology)
• Rats
• Rats, Wistar