Differentiation of desquamative interstitial pneumonia (DIP) from pulmonary adenocarcinoma by immunocytochemistry.

Abstract

AIM:

After a misdiagnosis of pulmonary adenocarcinoma as desquamative interstitial pneumonia (DIP), we investigated whether immunohistochemical markers could differentiate these conditions.

METHODS AND RESULTS:

Three cases of DIP and one pulmonary adenocarcinoma masquerading as DIP were studied by light and electron microscopy. All cases were mucin-negative. The cases of DIP were CD68 positive but cytokeratin-negative. The adenocarcinoma was cytokeratin-positive (AE1/3 and CAM5.2), as well as showing some CD68-positive cells. Markers for carcinoma (CEA, Ber-EP4, and Leu M1) were negative in all cases. Ultrastructurally the adenocarcinoma appeared to be derived from Type II pneumocytes.

CONCLUSION:

Before a diagnosis of DIP is made, cytokeratin markers should be used.

• Authors: A E Mutton, P S Hasleton, A Curry, P W Bishop, J Egan, K B Carroll, S Hanley
• Journal: Histopathology (Histopathology) Vol. 33 Issue 2 Pg. 129-35 (Aug 1998) ISSN: 0309-0167 [Print] England
• PMID: 9762545 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers

Topics

• Adenocarcinoma (chemistry, pathology, ultrastructure)
• Adult
• Biomarkers (analysis)
• Diagnosis, Differential
• Fatal Outcome
• Female
• Humans
• Immunohistochemistry
• Lung (chemistry, ultrastructure)
• Lung Diseases, Interstitial (pathology)
• Lung Neoplasms (chemistry, pathology, ultrastructure)
• Male
• Microscopy, Electron
• Middle Aged