Abstract | BACKGROUND: METHODS AND RESULTS: Transcranial Doppler ultrasound recordings from the ipsilateral middle cerebral artery were made after carotid endarterectomy in 12 control patients and 12 patients receiving intravenous GSNO from the induction of anesthesia until 2 hours after skin closure. Recording times were 0.5 to 3.5, 6 to 7, and 24 to 25 hours after skin closure. The Doppler signal was recorded onto tape, and analysis for ES was performed, with the investigators blinded to treatment group. All patients received aspirin 300 mg/d before surgery and 5000 IU of heparin during surgery. The median (range) number of ES detected during the initial 3-hour postoperative recording was markedly reduced in the GSNO group compared with the control group: 7.5 (0 to 61) versus 38.5 (1 to 219) (P=0.018). This difference persisted until 6 hours after surgery. CONCLUSIONS: Despite the administration of aspirin and heparin, frequent embolization occurred and was markedly reduced after the administration of GSNO. This demonstrates the potential use of platelet-specific nitric oxide donors in the treatment of thromboembolic disease. This model of cerebral embolism may allow determination of the effectiveness of new antiplatelet agents in humans.
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Authors | J Molloy, J F Martin, P A Baskerville, S C Fraser, H S Markus |
Journal | Circulation
(Circulation)
Vol. 98
Issue 14
Pg. 1372-5
(Oct 06 1998)
ISSN: 0009-7322 [Print] United States |
PMID | 9760290
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticoagulants
- Nitric Oxide Donors
- Nitroso Compounds
- Platelet Aggregation Inhibitors
- S-Nitrosoglutathione
- Heparin
- Glutathione
- Aspirin
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Topics |
- Aged
- Anticoagulants
(therapeutic use)
- Aspirin
(administration & dosage, therapeutic use)
- Carotid Stenosis
(surgery)
- Endarterectomy, Carotid
- Female
- Glutathione
(analogs & derivatives, therapeutic use)
- Heparin
(therapeutic use)
- Humans
- Incidence
- Intracranial Embolism and Thrombosis
(diagnostic imaging, epidemiology, prevention & control)
- Male
- Middle Aged
- Nitric Oxide Donors
(therapeutic use)
- Nitroso Compounds
(therapeutic use)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Postoperative Complications
(diagnostic imaging, epidemiology, prevention & control)
- Premedication
- Risk Factors
- S-Nitrosoglutathione
- Single-Blind Method
- Ultrasonography, Doppler, Transcranial
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