Multiple classes of the oligodendrocyte lineage are highly vulnerable to excitotoxicity.

Abstract

We have recently shown that galactocerebroside (Gal-C)-expressing oligodendrocytes are highly vulnerable to (AMPA)/kainate receptor-mediated death. Here we examined the vulnerability of cells at different developmental stages of the oligodendrocyte lineage to AMPA/kainate receptor-mediated excitotoxicity. Oligodendrocyte precursor cells, pre-oligodendrocytes and mature oligodendrocytes were killed by 24 h exposures to low concentrations of kainate (30-100 microM). Death was attenuated by the AMPA/kainate receptor antagonist 6-nitro-7-sulfamoylbenzo(f)quinoxaline-2,3-dione (NBQX). The high vulnerability of oligodendrocytes and their precursors to AMPA/kainate receptor excitotoxicity may represent an important mechanism of white matter damage resulting from trauma or ischemia in the perinatal and adult central nervous system (CNS).

• Authors: J W McDonald, J M Levine, Y Qu
• Journal: Neuroreport (Neuroreport) Vol. 9 Issue 12 Pg. 2757-62 (Aug 24 1998) ISSN: 0959-4965 [Print] England
• PMID: 9760116 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Excitatory Amino Acid Antagonists
• Excitatory Amino Acids
• Quinoxalines
• Receptors, AMPA
• Receptors, Kainic Acid
• 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline

Topics

• Animals
• Astrocytes (physiology)
• Cell Lineage (drug effects, physiology)
• Coculture Techniques
• Excitatory Amino Acid Antagonists (toxicity)
• Excitatory Amino Acids (toxicity)
• Immunohistochemistry
• Mice
• Oligodendroglia (drug effects, physiology)
• Prosencephalon (cytology)
• Quinoxalines (toxicity)
• Receptors, AMPA (drug effects)
• Receptors, Kainic Acid (drug effects)