Abstract | OBJECTIVE: STUDY DESIGN: A population-based case-control study, the Leiden Thrombophilia Study. MATERIALS AND METHODS: We investigated 99 pre-menopausal women, age 15-49 years, who had used oral contraceptives at the time of a first, objectively confirmed episode of deep-vein thrombosis. They were not pregnant, nor in puerperium, nor had had a recent miscarriage, and were not using injectable progestogens, nor suffering from inherited coagulation defects. The median time between occurrence of deep-vein thrombosis and venepuncture was 18 months, and 30 of the 99 women were still using oral contraceptives, while 69 had discontinued oral contraceptive use. In addition, a group of 153 control women (54 of them were oral contraceptive users and 99 were non-users) were studied. The following hemostatic variables were measured: APTT, factor VII, factor VIII, factor XII, fibrinogen, prothrombin, total antithrombin, normalised activated protein C sensitivity ratio ( n-APC-sr), protein C, protein S and free protein S. RESULTS: CONCLUSIONS: Our results of the effects of oral contraceptives generally confirm previous reports in healthy volunteers. Our data also show that in former deep-vein thrombosis patients these effects are more pronounced. Apparently some women become "high hemostatic responders" when exposed to oral contraceptives, and they may be the women most vulnerable to its thrombogenic effects.
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Authors | K W Bloemenkamp, F R Rosendaal, F M Helmerhorst, T Koster, R M Bertina, J P Vandenbroucke |
Journal | Thrombosis and haemostasis
(Thromb Haemost)
Vol. 80
Issue 3
Pg. 382-7
(Sep 1998)
ISSN: 0340-6245 [Print] Germany |
PMID | 9759614
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Abortion, Spontaneous
- Adult
- Contraceptives, Oral
(adverse effects)
- Female
- Hemostasis
(drug effects)
- Humans
- Middle Aged
- Pregnancy
- Thrombophlebitis
(blood, etiology)
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