Characterization of thiamine pyrophosphatase positive phagocytic cells in the neural lobe of rat pituitary.

Abstract

Here, using a histochemical staining for a microglia/phagocyte marker TPP-ase (Murabe, Sano 1981), and an electron microscopy we characterized the population of pituitary phagocytic cells activated by cerebral ischemia. An intense thiamine pyrophosphatase (TPP-ase) activity was demonstrated in glial cells and some cells of blood vessels of neural lobe, late period (12 months) after experimental ischemia. TPP-ase positive cells were ultrastructurally identified as pituicytes, microglia, pericytes and perivascular cells. The product characteristic for TPP-ase activity was seen on plasma membrane of these cells. Our electron-microscopic histochemical results provide strong support for a role of pituicytes, pericytes and perivascular cells as a phagocytic cells involved in mechanism of elimination of ischemically damaged axonal endings in neural lobe.

• Authors: B Gajkowska, M Walski, H Olszewska
• Journal: Folia neuropathologica (Folia Neuropathol) Vol. 36 Issue 2 Pg. 109-16 ( 1998) ISSN: 1641-4640 [Print] Poland
• PMID: 9757622 (Publication Type: Journal Article)

Chemical References

• Thiamine Pyrophosphatase

Topics

• Animals
• Brain Ischemia (enzymology)
• Cell Membrane (ultrastructure)
• Phagocytes (ultrastructure)
• Pituitary Gland (enzymology)
• Rats
• Rats, Wistar
• Thiamine Pyrophosphatase (metabolism)