Role of curdlan sulfate in the production of beta-chemokines and interleukin-16.

Abstract

The blocking effect of curdlan sulfate (CRDS) on human immunodeficiency virus (HIV) infection has been thought to be related to inhibition of the binding of HIV-1 envelope glycoprotein (gp120) and CD4 molecules. However, recent reports have indicated that blocking the binding of gp120 to CD4 by CRDS only makes a small contribution to the inhibition of HIV-1 infection. We report here that the effect of CRDS on the production of beta-chemokines and cytokines might be important in the inhibition of HIV-1 infection, in addition to interference with the binding of gp120 to CD4+ cells.

• Authors: T Naito, N Takeda-Hirokawa, H Kaneko, I Sekigawa, T Matsumoto, H Hashimoto, Y Kaneko
• Journal: Medical microbiology and immunology (Med Microbiol Immunol) Vol. 187 Issue 1 Pg. 43-8 (Jun 1998) ISSN: 0300-8584 [Print] Germany
• PMID: 9749981 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Chemokine CCL4
• Chemokines, CC
• Glucans
• HIV Envelope Protein gp120
• Interleukin-16
• Macrophage Inflammatory Proteins
• beta-Glucans
• curdlan sulfate

Topics

• Antiviral Agents (pharmacology)
• Cells, Cultured
• Chemokine CCL4
• Chemokines, CC (immunology, metabolism)
• Glucans (pharmacology)
• HIV Envelope Protein gp120 (drug effects, metabolism)
• HIV-1 (drug effects)
• Humans
• Interleukin-16 (immunology, metabolism)
• Leukocytes, Mononuclear (virology)
• Macrophage Inflammatory Proteins (immunology, metabolism)
• beta-Glucans