The effects of two commercially available intraocular irrigating solutions,
Opeguard MA and
BSS Plus, were studied during extracapsular
cataract surgery in 45 eyes of 35 patients. After irrigation and aspiration of the residual cortex with
Opeguard MA or
BSS-Plus, the ERG amplitude increased, respectively, to 111.2+/-5.8% and 109.5+/-5.3% of the preirrigation amplitudes. The increases reached significance (116.9+/-7.0% and 115.7+/-6.5%; both P < .05) at the end of surgery compared with pre-irrigation ERG amplitudes. After irrigation with
Opeguard MA or
BSS-Plus, the ERG peak times were significantly prolonged to 103.9+/-0.8% and 104.2+/-1.2%, respectively, of the preirrigation peak times (both P < .01). The ERG peak times significantly shortened to 101.5+/-0.9% and 101.3+/-1.22%, respectively, at the end of surgery (P < .001 and P < .05) compared with just after irrigation. Although we have previously shown that
Opeguard MA maintained amplitude and implicit time of 30 Hz flicker ERG during
vitrectomy better than
BSS-Plus, there were no statistically significant differences between the changes in amplitude and peak time with
Opeguard MA and
BSS-Plus during
cataract surgery. We speculate that a drop in the
retinal temperature during irrigation and aspiration in the anterior chamber and an increase in the photopic ERG amplitude during light adaptation with the operating microscope caused these ERG changes.