No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses.

Abstract

Atopic dermatitis (AD) is a chronic relapsing dermatitis which belongs to the group of atopy-related diseases as well as asthma and allergic rhinitis. As a probable genetic risk which may contribute to the organ specificity of AD, an association between AD and a genetic variant of the gene encoding mast cell chymase (MCC), which has chymotrypsin-like specificity and is abundant in skin mast cells, has been reported in a Japanese population. We tried to confirm the role of this polymorphism in the development of AD in a Japanese population. A case-control analysis using 100 AD patients and 101 controls did not show a significant difference in the frequency of the BB genotype between the patient and control groups (odds ratio 1. 12, p = 0.81). The haplotype relative-risk analysis using 69 patient-parents trios did not suggest an association (chi2 = 0.177, p = 0.92). Thus, we failed to confirm the association between the polymorphism in the MCC gene and AD in the Japanese population.

• Authors: T Kawashima, E Noguchi, T Arinami, K Kobayashi, F Otsuka, H Hamaguchi
• Journal: Human heredity (Hum Hered) 1998 Sep-Oct Vol. 48 Issue 5 Pg. 271-4 ISSN: 0001-5652 [Print] Switzerland
• PMID: 9748697 (Publication Type: Journal Article)

Chemical References

• Serine Endopeptidases
• Chymases

Topics

• Adult
• Case-Control Studies
• Child
• Chymases
• Dermatitis, Atopic (enzymology, genetics)
• Haplotypes
• Humans
• Mast Cells (enzymology)
• Odds Ratio
• Serine Endopeptidases (genetics)