[Pretibial epidermolysis bullosa. A rare form of epidermolysis bullosa simplex].

Abstract

INTRODUCTION:

Pretibial epidermolysis bullosa had been classified as a rare localized form of autosomal dominant dystrophic epidermolysis bullosa.

OBSERVATION:

We report a sporadic case of a patient suffering from bullous lesions induced by minor trauma on pretibial skin. The lesions healed with atrophic scars. No milia formation was observed. The mapping of dermoepidermal junction by LH 7:2 and GB3 monoclonal antibodies was normal. By electron microscopy, numerous perinuclear vacuoles were observed and the cleavage occurred within the basal keratinocytes.

DISCUSSION:

This patient had clinical features in accordance with a diagnosis of pretibial epidermolysis bullosa. However, in contrast to previous case reports, the ultrastructural pattern was this of an epidermolysis bullosa of simplex type.

• Authors: P Tsianakas, S Fraitag, A Archimbaud, O Verola, C Paul, C Prost
• Journal: Annales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 125 Issue 1 Pg. 34-6 (Jan 1998) ISSN: 0151-9638 [Print] France
• Vernacular Title: Epidermolyse bulleuse prétibiale. Une forme inhabituelle d'épidermolyse bulleuse simple.
• PMID: 9747205 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adult
• Epidermolysis Bullosa Simplex (etiology, pathology)
• Humans
• Keratinocytes (ultrastructure)
• Leg Dermatoses (etiology, pathology)
• Leg Injuries (complications)
• Male
• Tibia