Abstract | PURPOSE: METHODS: Biopsy material from one native human ovarian carcinoma was expanded and transplanted into 48 nude mice. The animals were divided into six treatment groups: cisplatin 3x4 mg/kg, paclitaxel 5x26 mg/kg, vinorelbine 1x20 mg/kg, titanocene dichloride 3x30 mg/kg, titanocene dichloride 3x40 mg/kg and a control group treated with 0.9% saline. Treatment groups were evaluated in terms of average daily increase in tumour volume and average daily body weight increase of the nude mice based on slopes of least square regressions performed on individual animals. The slope factors alpha and beta of the body weight (alpha) and tumour volume changes (beta) within each group were calculated. RESULTS: CONCLUSION:
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Authors | M Friedrich, C Villena-Heinsen, C Farnhammer, W Schmidt |
Journal | European journal of gynaecological oncology
(Eur J Gynaecol Oncol)
Vol. 19
Issue 4
Pg. 333-7
( 1998)
ISSN: 0392-2936 [Print] Singapore |
PMID | 9744720
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Organometallic Compounds
- Vinblastine
- titanocene dichloride
- Paclitaxel
- Cisplatin
- Vinorelbine
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Body Weight
(drug effects)
- Cisplatin
(pharmacology)
- Female
- Humans
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Organometallic Compounds
(pharmacology)
- Ovarian Neoplasms
(pathology)
- Paclitaxel
(pharmacology)
- Transplantation, Heterologous
- Vinblastine
(analogs & derivatives, pharmacology)
- Vinorelbine
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