[The efficacy of polychemotherapy programs in treating multiple myeloma patients].

Abstract

AIM:

To compare efficiency of the programs MCVP, VCAP and ARA-COP in the treatment of multiple myeloma (MM) as regards completeness of the response, duration of the remission and toxicity.

MATERIALS AND METHODS:

A total of 41 MM patients entered the study (27 females, 14 males, age from 41 to 72 years, MM duration from 1 month to 8 years). 16, 10 and 15 patients were treated according to MCVP, VCAP and ARA-COP programs.

RESULTS:

Both in the resistant and primary patients the response was the highest to ARA-COP treatment. The remission or stabilization was achieved in 93.4% of patients. VCAP program was less effective. However, clinicohematological remission was achieved in 50% of patients. This program is rather heart toxic. MCVP program was the least effective. Survival was followed up in 16 patients (10 MCVP, 3 VCAP and 3 ARA-COP patients). The survival was 20-62, 16-36, 23.6-64.8 months for ARA-COP, VCAP and MCVP, respectively.

CONCLUSION:

ARA-COP program proved most effective of the three programs both in primary and drug-resistant patients. VCAP and MCVP programs are less effective but can be used in primary management of MM patients.

• Authors: S S Bessmel'tsev, K M Abdulkadyrov, O A Rukavitsyn
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 70 Issue 7 Pg. 46-9 ( 1998) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' nekotorykh programm polikhimioterapii pri lechenii bol'nykh mnozhestvennoĭ mielomoĭ.
• PMID: 9742636 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Cytarabine
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisolone
• Melphalan
• Prednisone

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cyclophosphamide (administration & dosage)
• Cytarabine (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Evaluation
• Female
• Humans
• Male
• Melphalan (administration & dosage)
• Middle Aged
• Multiple Myeloma (drug therapy)
• Prednisolone (administration & dosage)
• Prednisone (administration & dosage)
• Remission Induction
• Vincristine (administration & dosage)