A thirty day course of sodium stibogluconate for treatment of Kala-azar in Nepal.

Abstract

Twenty-seven cases of Kala-azar were treated with sodium stibogluconate at a dose of 20 mg/kg/day for 20 days (group A) and an equal number of cases were treated with the same dose but for a longer duration of 30 days (group B). Clinical and laboratory evaluation of these cases were carried out before and after therapy, during a follow up of cases every month, upto 6 months. Renal and liver function tests and electrocardiography were carried out of monitor any toxic effect of the drug during therapy. The cure rates of patients were 77.78% and 92.59% in group A and B cases respectively. Six and two patients in group A and B respectively were unresponsive to the treatment and showed relapse. Results of the study show that treatment of cases of Kala-azar with sodium stibogluconate in a dosage of 20 mg/kg/day for a longer period of 30 days is effective with a higher cure rate and minimum side effects, for treatment of cases of Kala-azar in this eastern part of Nepal, endemic for the disease.

• Authors: P Karki, S Koirala, S C Parija, S G Hansdak, M L Das
• Journal: The Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 29 Issue 1 Pg. 154-8 (Mar 1998) ISSN: 0125-1562 [Print] Thailand
• PMID: 9740292 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antiprotozoal Agents
• Antimony Sodium Gluconate

Topics

• Adolescent
• Adult
• Antimony Sodium Gluconate (administration & dosage, therapeutic use)
• Antiprotozoal Agents (administration & dosage, therapeutic use)
• Child
• Female
• Humans
• Leishmaniasis, Visceral (drug therapy)
• Male
• Middle Aged
• Nepal