Abstract | OBJECTIVE: To explore new tumor features for refined category formation that permits the tailoring of individualized treatment schemes in lung cancer. STUDY DESIGN: RESULTS: In all studies, a correlation between tumor parameters, according to TNM stage and survival, was seen. In order to refine this category formation, at least certain selected features should provide an even more stringent association than TNM stages. Indeed, statistical correlation of the cytometric and histometric parameters as well as the expression of receptors for the two histo- blood group trisaccharides, ligands for the galectins (CL-16, CL-14) and macrophage migration inhibitory factor was stronger than that of TNM stage. A large amount of the current of structural entropy was especially highly significantly associated with poor survival. This observation could be verified in each of the different studies. CONCLUSION: The obtained data strongly support the notion that thermodynamic evaluation of tumor growth focusing on the "entropy distance" of the tumor from its environment is a promising perspective warranting extended studies. Additionally, glycohistochemical features, including binding capacities for histo- blood group trisaccharides, have the potential to aid in establishment of a biologic marker set for tumor staging.
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Authors | K Kayser, G Kayser, S Eichhorn, U Biechele, M Altiner, H Kaltner, F Y Zeng, E V Vlasova, N V Bovin, H J Gabius |
Journal | Analytical and quantitative cytology and histology
(Anal Quant Cytol Histol)
Vol. 20
Issue 4
Pg. 313-20
(Aug 1998)
United States |
PMID | 9739414
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Ligands
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Topics |
- Biomarkers, Tumor
- Entropy
- Female
- Histocytochemistry
- Humans
- Image Cytometry
(methods)
- Ligands
- Lung Neoplasms
(chemistry, pathology, surgery)
- Multivariate Analysis
- Prognosis
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