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The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats.

Abstract
The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H3-agonist [(R)-alpha-methylhistamine] and H1-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H2-antagonist (cimetidine and ranitidine) caused no antagonistic effect. Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment.
AuthorsH Kakinoki, K Ishizawa, M Fukunaga, Y Fujii, C Kamei
JournalBrain research bulletin (Brain Res Bull) Vol. 46 Issue 5 Pg. 461-5 (Jul 15 1998) ISSN: 0361-9230 [Print] United States
PMID9739010 (Publication Type: Journal Article)
Chemical References
  • Enzyme Inhibitors
  • Histamine Antagonists
  • Imidazoles
  • Piperidines
  • Receptors, Histamine H3
  • metoprine
  • Histamine N-Methyltransferase
  • Thiourea
  • thioperamide
  • clobenpropit
  • Pyrimethamine
Topics
  • Amygdala (physiology)
  • Animals
  • Brain Chemistry (drug effects)
  • Enzyme Inhibitors (pharmacology)
  • Histamine Antagonists (pharmacology)
  • Histamine N-Methyltransferase (antagonists & inhibitors)
  • Imidazoles (administration & dosage, pharmacology)
  • Injections, Intraventricular
  • Kindling, Neurologic (physiology)
  • Male
  • Piperidines (administration & dosage, pharmacology)
  • Pyrimethamine (analogs & derivatives, pharmacology)
  • Rats
  • Rats, Wistar
  • Receptors, Histamine H3 (metabolism)
  • Seizures (physiopathology)
  • Thiourea (administration & dosage, analogs & derivatives, pharmacology)

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