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Baclofen, a treatment for chronic hiccup.

Abstract
The efficacy of baclofen in the treatment of chronic hiccup is demonstrated in two cases. These cases highlight the present state of knowledge related to hiccup. This discussion focuses on the definition and classification of hiccup, etiologies, postulated theories to explain its function, the few studies performed to date, and non-pharmacologic and pharmacologic treatment. Baclofen appears to be the agent most efficacious in the treatment of chronic hiccup. Its commonest side effect is sedation; insomnia, dizziness, weakness, ataxia, and confusion also can occur. Following regular use, abrupt discontinuation can lead to withdrawal symptoms, such as seizure, and gradual discontinuation is recommended.
AuthorsP Walker, S Watanabe, E Bruera
JournalJournal of pain and symptom management (J Pain Symptom Manage) Vol. 16 Issue 2 Pg. 125-32 (Aug 1998) ISSN: 0885-3924 [Print] United States
PMID9737104 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Muscle Relaxants, Central
  • Baclofen
Topics
  • Aged
  • Baclofen (therapeutic use)
  • Chronic Disease
  • Hiccup (drug therapy)
  • Humans
  • Male
  • Muscle Relaxants, Central (therapeutic use)

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