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Synergism between poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose glucan and cefazolin in prophylaxis of staphylococcal wound infection in a guinea pig model.

Abstract
To determine whether the infection-preventing capability of the neutrophil-activating agent poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose glucan (PGG-glucan) can be enhanced with antibiotic prophylaxis, we administered PGG-glucan and cefazolin, alone and in combination, to guinea pigs inoculated with isolates of staphylococci. Guinea pigs receiving both PGG-glucan and cefazolin had 50% infective doses that were 8- to 20-fold higher than those obtained with cefazolin alone and 100- to 200-fold higher than those obtained with PGG-glucan alone. PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.
AuthorsA B Kaiser, D S Kernodle
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 42 Issue 9 Pg. 2449-51 (Sep 1998) ISSN: 0066-4804 [Print] United States
PMID9736583 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Adjuvants, Immunologic
  • Cephalosporins
  • Glucans
  • beta-Glucans
  • poly-1-6-glucopyranosyl-1-3-glucopyranose glucan
  • Cefazolin
Topics
  • Adjuvants, Immunologic (therapeutic use)
  • Animals
  • Antibiotic Prophylaxis
  • Cefazolin (administration & dosage, therapeutic use)
  • Cephalosporins (therapeutic use)
  • Drug Synergism
  • Female
  • Glucans (administration & dosage, therapeutic use)
  • Guinea Pigs
  • Male
  • Staphylococcal Infections (prevention & control)
  • Wound Infection (prevention & control)
  • beta-Glucans

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