Protective effect of oral administration of a traditional medicine, Juzen-Taiho-To, and its components on lethal Candida albicans infection in immunosuppressed mice.

Abstract

Protective effects of a kampo medicine, Juzen-taiho-to (TJ-48) and its herbal components against experimental candidiasis in cyclophosphamide-induced immunosuppressive mice were investigated. ICR mice were immunosuppressed by intraperitoneal treatment with cyclophosphamide (day-4) and were orally given TJ-48 or one of its 10 herbal components for 4 consecutive days (day-4--1). They were then challenged intravenously with a lethal dose of Candida albicans (day 0). An oral dose of 1 g/kg/day of TJ-48 prolonged their life span. A similar protective effect was obtained by treatment with its component drugs Ginseng radix, Glycyrrhizae radix, Atractylodis lancea rhizoma or Cnidii rhizoma. These herbal components were suggested to have a main role in the protective effect of Juzen-taiho-to against Candida infection.

• Authors: S Abe, S Tansho, H Ishibashi, N Inagaki, Y Komatsu, H Yamaguchi
• Journal: Immunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 20 Issue 3 Pg. 421-31 (Aug 1998) ISSN: 0892-3973 [Print] England
• PMID: 9736446 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Drugs, Chinese Herbal
• juzentaihoto
• Cyclophosphamide

Topics

• Adjuvants, Immunologic (therapeutic use)
• Administration, Oral
• Animals
• Candidiasis (prevention & control)
• Cyclophosphamide (pharmacology)
• Drugs, Chinese Herbal (administration & dosage, therapeutic use)
• Female
• Immunosuppression Therapy
• Mice
• Mice, Inbred ICR